Aspergillus endocarditis in man usually occurs on prosthetic cardiac valves and gives rise to
large vegetations which embolize easily producing peripheral organ infarction and infection.
Blood cultures are usually sterile and the disease is difficult to cure with antimicrobial
agents. Aspergillus endocarditis was studied in rabbits to determine the course, degree of
fungemia, and response to treatment with amphotericin B (A), 5 flucytosine (5 FC) or A+ 5
FC. Polyethylene tubing was introduced into the left ventricle through the carotid artery and …